How do I open Warren's safe?
There are several clues in the room.
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Read the note in the side table.
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Names and numbers. Have you noticed these names anywhere?
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Look at the collection of framed pictures.
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Specifically the John & Lesley picture, and the Naomi picture. The highlighted words spell out a message.
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Follow their advice and look behind the suits in the wardrobe.
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Another cryptic message demanding things of you. Use the toothpicks you found on the table with the toothpick puzzle. Tap a number to add toothpicks to it, again to remove.
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Add two toothpicks to 9 and two toothpicks to 1 to turn them into 8 and 4.
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You now have the code to the safe. 8 6 4 8.